Heating Up the Cutaneous Flushing Response

Heating up the cutaneous flushing response.

Heating up the cold bounce

Self-dual string cosmological models provide an effective example of bouncing solutions where a phase of accelerated contraction smoothly evolves into an epoch of decelerated Friedmann–Robertson–Walker expansion dominated by the dilaton. While the transition to the expanding regime occurs at sub-Planckian curvature scales, the Universe emerging after the bounce is cold, with sharply growing gau...

The involvement of heating rate and vasoconstrictor nerves in the cutaneous vasodilator response to skin warming.

Slow local skin heating (LH) causes vasodilator responses, some of which are dependent on sympathetic nerve function. It is not known, however, how the rate of LH affects either the sympathetic or the nonadrenergic components of the responses to LH and whether the adrenergic effects of LH depend on tonic sympathetic activity or whether LH stimulates transmitter release. In part 1, cutaneous vas...

Cutaneous Vasodilation during Local Heating: Role of Local Cutaneous Thermosensation

We tested the hypothesis that cutaneous vasodilation during local skin heating in humans could be manipulated based upon the ability to desensitize TRPV4 ion channels by applying the thermal stimuli in a series of pulses. Each subject was instrumented with intradermal microdialysis probes in the dorsal forearm skin and perfused with 0.9% saline at 1.5 μl/min with local skin temperature controll...

Intradermal angiotensin II administration attenuates the local cutaneous vasodilator heating response.

The vasodilation response to local cutaneous heating is nitric oxide (NO) dependent and blunted in postural tachycardia but reversed by angiotensin II (ANG II) type 1 receptor (AT(1)R) blockade. We tested the hypothesis that a localized infusion of ANG II attenuates vasodilation to local heating in healthy volunteers. We heated the skin of a calf to 42 degrees C and measured local blood flow to...